MicrocynVS®

Microcyn® Technology

Natural body ingredients that boost your immune system

Tightly controlled chemistry resulting in unmatched stability. Our Microcyn® technology is based on one of the body’s most important molecules: Hypochlorous acid (HOCl).

Launched in 2004, it was the first revolutionary stable patented HOCl formulation in a bottle. With virtually no side effects or contraindications, you can utilize our solutions as often as needed to cleanse skin, relieve irritations and restore your well-being and peace of mind.

Microcyn® Technology – Safe as water

In-vitro and clinical studies of Hypochlorous Acid (HOCl) show it to have impressive antipruritic, antimicrobial and anti-inflammatory properties. The Microcyn® Technology not only optimizes HOCl for superior efficacy and safety, it guarantees potency for the life of the product. With virtually no side effects or contraindications, you can utilize Microcyn®-based products as often as needed to cleanse skin, relieve irritations and restore your well-being and peace of mind.

Cleanse

Relieve

Restore

Triple Mode of Action

Based on one of the body’s most important molecules, Hypochlorous acid (HOCl), Microcyn® Technology has a Triple Mode of Action and profound impact on infection, inflammation and scarring:

Anti-Microbial	Anti-Inflammatory	Regenerative
In-vitro and clinical studies of Microcyn Technology breaks down the biofilm along with having impressive anti-pruritic, anti-microbial, anti-viral and anti-inflammatory properties.	A powerful anti-inflammatory, our products treat common conditions while reducing infections, itch, pain, scarring and harmful inflammatory responses.	A gentle and safe solution that increases blood/oxygen flow to the wound, resulting in faster, more effective healing.

Microcyn® Technology Applications


Cleanse	Relieve	Restore
Safely eradicates biofilm and other irritants.	Reduces inflammation, pain, itch and swelling fast.	Increasing oxygen to the area in need helps
Time Kill Study: In Vitro in solution HOCl Eradication of Pathogens Greater than 99% reduction in killing 23 different microorganisms	Open-label, single-arm study over 7 day Results HOCl rapidly reduces pruritus in mild-to-moderate atopic dermatitis (AD) Greater than 99% reduction in killing 23 different microorganisms	Provides higher levels of oxygen at a wound site after application Elevated blood and oxygen flow increases wound-healing nutrients HOCl is a known vasodilator
Biofilm formation is recognized as a serious problem in chronic wound infections. HOCl has antibiofilm activity6 and actively breaks down biofilm and kills microorganisms within the biofilm. Biofilm characteristics include: Complex structure of microorganisms that generate a protective shell, allowing bacteria to collect and proliferate Most microorganisms that form biofilms found growing in microbial infection. Adheres to chronic wounds, makes phagocytosis difficult, and increases resistance to antibiotics Greater than 99% reduction in killing 23 different microorganisms	72-hour study Treated group (n=19): HOCI BID Untreaded group (n=10): No Treatment Results The mean pruritus VAS scores saw a greater improvement among the treated group than the untreated group between baseline and 72 hours post application	Wound healing involves a complex sequence of events. Fibroblasts are the primary synthetic cells in the repair process of most structural proteins used during tissue reconstruction. At lower concentrations of HOCl, the percentage of fibroblast migration exceeded that of the control at 24 hours.
	Microcyn Technology for Inhibition of Mast Cell Degranulation Prevents allergen and calcium-induced mast cell degranulation for up to 8 hours after a single exposure in vitro Reduces wound inflammation that inhibits healing Stabilizes the mast cell membrane to inhibit the cell machinery for granule secretion, while not altering the signal transduction pathways or calcium mobilization Inhibits degranulation stimulated by antigen or calcium ionophore

Unique chemistry

The main component, hypochlorous acid (HOCl), is naturally produced as part of our immune system during phagocytosis. When neutrophils encounter bacteria or other pathogens, the neutrophils engulf it, generate HOCl and instantly destroys the microorganism. This process is called the “oxidative burst”.

During the activation of neutrophils, ‘respiratory bursts’ generate hydrogen peroxide (H2O2) and the activated granule enzyme myeloperoxidase converts H2O2 into hypochlorous acid (HOCl).